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Rehab News:Research, Heart drug could combat cocaine cravings

New research indicates that a common heart drug could offer a solution to combating cocaine cravings.

Researchers from Boston University School of Medicine and Harvard Medical School looked at the effect of diltiazem, a drug usually used to treat high blood pressure, on rats.

The study found that the drug reduced the animals' cocaine cravings, disrupting the connection between the neurotransmitters dopamine and glutamate, which have in the past been shown to contribute to the development of cocaine addiction.

Dilitiazem is known as a calcium channel blocker. The researchers said that calcium plays an important role in learning and memory, influencing an enzyme known as the "memory molecule", which in effect teaches the brain how to become addicted.

Senior author Chris Pierce, a professor of pharmacology and psychiatry at Boston University School of Medicine, said that this work suggests knowledge about "something fundamental" about how "brain chemistry changes as cocaine addiction takes hold".

He added: "Importantly, our findings also suggest new strategies for developing cocaine addiction therapies, which thus far remain elusive."

The findings will appear in the March issue of medical journal Nature Neuroscience.

Other research published this week suggested that there is a biological reason why some people become long-term cocaine addicts, while others can use the drug socially without becoming dependent.