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Rehab News:More physiological effects of alcohol on the brain revealed

For the first time, a physiological basis for the effect of alcohol on male sexual behaviour, including increased sexual arousal and decreased sexual inhibition, has been discovered.

Researchers at Penn Sate have used an animal model to reveal that male fruit flies, which typically court females, also actively court males when they are given a daily dose of ethanol.

Research team leader Kyung-An Han explained that because the researchers suspect that behavioral sensitisation results from adaptive changes in the brain's cells and molecules induced by chronic alcohol consumption, they plan to use behavioural sensitisation as a model for further physiological studies of alcohol-associated behaviour and addiction.

"This part of our study demonstrates that sexual behaviour is not determined only during an organism's development, but it also can be influenced by a post-developmental environmental factor; in this case, recurring exposure to ethanol," Dr Han said.

"These findings represent the first demonstration of enduring behavioural changes induced by recurring ethanol exposure in a fly model."

He added: "As a result of our research with the fruit fly, we are now just beginning to discover the molecular and cellular mechanisms underlying neural changes in the brain that result from the chronic use of alcohol and that result in alcohol addiction and other behaviour changes in our fly model."

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