UK - Residential Clinic

Looking for a rehab clinic/treatment centre in the UK area?

You can receive independent, expert advice on alcohol rehabilitation and rehab centres by telephoning directly on 0117 339 0080.

The most important consideration in choosing a rehab centre is to match the individual to the rehab centre that is most likely to lead to a successful outcome.

We can provide an assessment of all your needs and a recommendation regarding the most effective rehab placement for you, given your particular circumstances. We can provide fast, immediate access to alcohol treatment.

Rehab News:Mechanism behind Cocaine Craving Identified

A possible future way to prevent relapses into drug dependence has been discovered by researchers at Linkaping University and the German cancer research center DKFZ. The target is the dopamine-producing nerve cells in the midbrain.

Earlier research has shown that these cells become more excitable when a person takes drugs. To find out the functional meaning of this, these researchers used a mouse model for cocaine dependence. When they blocked the cells' receptors for glutamate the brain's most important signal substance the risk of relapsing into addiction vanished. The findings are being published in Neuron.

Dopamine-producing nerve cells are central to the brain's reward system. Dependence-inducing drugs cause concentrations of dopamine to rise in the surroundings, which in turn affects other nerve cells and brings about various physical and mental reactions.

Cocaine has a very rapid impact on dopamine levels, which explains why it is one of the most addictive drugs.

"When you take cocaine, the number of glutamate receptors increases, rendering the cell more excitable. When we block this process, we prevent relapses into addiction. This is interesting clinically since that is the phase when we can get hold of patients," says David Engblom, a neurobiologist at Linkaping University and the study's lead author.

An addict who wants to give up drugs could thus be offered a vaccination' against relapsing. But much more research remains to be done before such treatment can become a reality.

Reference: David Engblom et al. 'Glutamate Receptors on Dopamine Neurons Control the Persistence of Cocaine-Seeking', Neuron, August 14, 2008