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Rehab News:Gene variation linked to alcoholism in Mexicans

A new study has found that those of Mexican descent with a haplotype of a particular gene may be at increased risk of alcoholism.

Haplotypes are clusters of genetic polymorphisms or variations.

Information from 334 alcoholic and 365 non-alcoholic Mexican Americans living in the Los Angeles area was collected by researchers s at the University of Kansas Medical Center (UKMC).

They found that people carrying haplotype H6, the combination of the four alleles [copies] - 1C, c2, C and A2 - have increased susceptibility to developing alcoholism.

Hapoltype H6 is associated with late-age onset of drinking, as well as heavy drinking.

"Whether H6 changes enzyme activity or alcohol-induced enzyme activity needs to be examined," said report author Yu-Jui Yvonne Wan, a professor of pharmacology and director of the Liver Center at UKMC.

"Although only five per cent of Mexican alcoholics have the H6 haplotype, it is important to use the same approach to study other ethnic groups, particularly Asians, who have high frequency of both c2 and C alleles. Furthermore, since elevated CYP2E1 causes oxidative stress, polymorphisms of this gene might also have an impact on other disease processes such as cancer."