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Rehab News:Alcoholics with cirrhosis 'at higher risk of brain damage'

Alcoholics who have cirrhosis of the liver are more likely to suffer brain damage than non-cirrhotic alcoholics, experts have said.

Sustained drinking is known to cause liver scarring and dysfunction, known as cirrhosis.

It is also known to cause brain damage, but the latest research has found that this impairment of brain function is even worse if the drinker also suffers from cirrhosis.

Researchers at the University of Texas analysed brain samples taken from seven cirrhotic and 14 non-cirrhotic cases to determine the extent of genetic changes.

R. Dayne Mayfield, research scientist at the Waggoner Centre for Alcohol and Addiction Research at the University of Texas, commented: "We found that the levels of many important brain genes changed in the cirrhotic patients.

"These genes are important in regulating cell death and how individual cells in the brain talk to each other in a meaningful way."

John Krystal, professor of clinical pharmacology and deputy chairman for research in the department of psychiatry at Yale University School of Medicine, added: "The level of gene expression differed significantly between tissue from cirrhotic and non-cirrhotic alcoholics.

"With the levels of so many genes changing, this study suggests widespread effects in many cellular pathways related to cirrhosis in the alcoholic group."

The results are published in the journal of Alcoholism: Clinical and Experimental Research.