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Rehab News:Addiction gene 'jigsaw' assembled

The most comprehensive gene atlas for underlying drug addiction has been identified by Chinese researchers and they have identified five molecular pathways common to four different addictive drugs.

Researchers from the Center for Bioinformatics at Peking University in Beijing said studying individual or a small number of genes is like looking at pieces of a jigsaw puzzle - "only when you gather most of the pieces from different places and arrange them together in an orderly fashion do interesting patterns emerge".

Using an integrative meta-analysis approach the team, led by Liping Wei, surveyed scientific literature published in the past 30 years and collected 2,343 items of evidence linking genes and chromosome regions to addiction based on single-gene strategies, microarray, proteomics, or genetic studies.

Using this, the team identified 18 molecular pathways that are statistically enriched in the addiction-related genes.

They then identified five pathways that are common to addiction to four different substances. These common pathways may underlie shared rewarding and response mechanisms and may be targets for effective treatments for a wide range of addictive disorders, researchers said in the study, published in PLoS Computational Biology on January 4th, 2008.